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In essence, CagriSema (cagrilintide + semaglutide) tackles obesity through a dual-hormone approach: one component (semaglutide) powerfully reduces hunger and improves insulin/glucagon balance via GLP-1 receptors, while the other (cagrilintide) reinforces fullness and further curbs appetite via amylin receptorspubmed.ncbi.nlm.nih.gov

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We do not believe that the use of the term up to date or the update to the numerator will impact information collection or reporting burden because the modification changes neither the amount of data being submitted nor the frequency of data submission